Structure of PDB 7tic Chain D

Receptor sequence
>7ticD (length=322) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
PWVEKYRPKNLDEVTAQDHAVTVLKKTLKSANLPHMLFYGPPGTGKTSTI
LALTKELYGPDLMKSRILELNASDGISIVREKVKNFARLTVSKPSKHDLE
NYPCPPYKIIILDEADSMTADAQSALRRTMETYRFCLICNYVTRIIDPLA
SRCSKFRFKALDASNAIDRLRFISEQENVKCDDGVLERILDISAGDLRRG
ITLLQSASKGAQYLGDGKNITSTQVEELAGVVPHDILIEIVEKVKSGDFD
EIKKYVNTFMKSGWSAASVVNQLHEYYITNDNFDTNFKNQISWLLFTTDS
RLNNGTNEHIQLLNLLVKISQL
3D structure
PDB7tic Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader.
ChainD
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS D V28 R32 P33 P67 G68 T69 G70 K71 T72 S73 R200 L228 R229 V3 R7 P8 P42 G43 T44 G45 K46 T47 S48 R169 L197 R198
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000076 DNA replication checkpoint signaling
GO:0000077 DNA damage checkpoint signaling
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0007062 sister chromatid cohesion
GO:0007064 mitotic sister chromatid cohesion
GO:0090618 DNA clamp unloading
Cellular Component
GO:0005634 nucleus
GO:0005663 DNA replication factor C complex
GO:0031389 Rad17 RFC-like complex
GO:0031390 Ctf18 RFC-like complex
GO:0031391 Elg1 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tic, PDBe:7tic, PDBj:7tic
PDBsum7tic
PubMed35179493
UniProtP40348|RFC2_YEAST Replication factor C subunit 2 (Gene Name=RFC2)

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