Structure of PDB 7tdv Chain D

Receptor sequence

>7tdvD (length=442) Species: 1280 (Staphylococcus aureus)

TFTKEDIRKFVEEENVRYLRLQFTDILGTIKNVEVPVSQLEKVLDNEMMF
DGSSIEGFVRIEESDMYLHPDLDTWVIFPWTAGQGKVARLICDVYKTDGT
PFEGDPRANLKRVLKEMEDLGFTDFNLGPEPEFFLFKLDEKGEPTLELND
DGGYFDLAPTDLGENCRRDIVLELEDMGFDIEASHHEVAPGQHEIDFKYA
DAVTACDNIQTFKLVVKTIARKHNLHATFMPKPLFGVNGSGMHFNVSLFK
GKENAFFDPNTEMGLTETAYQFTAGVLKNARGFTAVCNPLVNSYKRLVPG
YEAPCYIAWSGKNRSPLIRVPSSRGLSTRIEVRSVDPAANPYMALAAILE
AGLDGIKNKLKVPEPVNQNIYEMNREEREAVGIQDLPSTLYTALKAMREN
EVIKKALGNHIYNQFINSKSIEWDYYRTQVSEWERDQYMKQY

3D structure

• PDB: 7tdv Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
• Chain: D
• Resolution: 2.92 Å

Enzymatic activity

• Enzyme Commision number: 6.3.1.2: glutamine synthetase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	D	G132 E134 E186 D200 F201 K202 Y203 N249 S251 R323 S331 R333	G128 E130 E182 D196 F197 K198 Y199 N245 S247 R319 S327 R329
BS02	P3S	D	E134 E136 E191 E198 G243 H247 R300 E306 R318 R337	E130 E132 E187 E194 G239 H243 R296 E302 R314 R333
BS03	MG	D	E134 E198	E130 E194
BS04	MG	D	E134 H247 E335	E130 H243 E331

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004356 glutamine synthetase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006542 glutamine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7tdv, PDBe:7tdv, PDBj:7tdv
• PDBsum: 7tdv
• PubMed: 35778410
• UniProt: E3VXC2