Structure of PDB 7t7m Chain D

Receptor sequence

>7t7mD (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]

PVERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDR
NITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFE
CNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCE
YVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCE
PNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLF
SCRCGSPKCRHS

3D structure

PDB

7t7m Discovery of the First-in-Class G9a/GLP Covalent Inhibitors.

Chain

Resolution

2.85 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.-
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	D	C1062 C1075 C1105 C1109	C58 C71 C101 C105
BS02	ZN	D	C1068 C1105 C1111 C1115	C64 C101 C107 C111
BS03	ZN	D	C1062 C1064 C1068 C1073	C58 C60 C64 C69
BS04	ZN	D	C1256 C1258	C252 C254
BS05	G5U	D	Y1155 D1162 D1166 D1171 L1174 F1175 D1176 C1186 Y1242 R1245 F1246	Y151 D158 D162 D167 L170 F171 D172 C182 Y238 R241 F242

Gene Ontology

	Molecular Function
GO:0002039	p53 binding
GO:0008270	zinc ion binding
GO:0016279	protein-lysine N-methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0046974	histone H3K9 methyltransferase activity

	Cellular Component
GO:0005634	nucleus

View graph for
Molecular Function

View graph for
Cellular Component

External links

PDB	RCSB:7t7m, PDBe:7t7m, PDBj:7t7m
PDBsum	7t7m
PubMed	35763668
UniProt	Q9H9B1\|EHMT1_HUMAN Histone-lysine N-methyltransferase EHMT1 (Gene Name=EHMT1)

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