Structure of PDB 7t3v Chain D

Receptor sequence
>7t3vD (length=517) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
ASEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNN
PGKENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNS
VAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNL
FRFFLETLFYEYMTDERFKSTDKNMEYIKHLGVYINNADTYKEEVEKARV
YYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEEL
KMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLK
AAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSK
NSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIAT
LTGAMLYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRAT
LNSKYADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKAR
KPKGFGVRLLTEFVLND
3D structure
PDB7t3v A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase.
ChainD
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.13.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO3 D A460 E461 G462 R463 L487 A374 E375 G376 R377 L401
BS02 ZN D K374 D379 D399 E461 K288 D293 D313 E375
BS03 ZN D D379 D459 E461 D293 D373 E375
Gene Ontology
Molecular Function
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7t3v, PDBe:7t3v, PDBj:7t3v
PDBsum7t3v
PubMed35691342
UniProtQ8IL11|AMPL_PLAF7 Leucine aminopeptidase (Gene Name=LAP)

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