Structure of PDB 7stz Chain D

Receptor sequence

>7stzD (length=422) Species: 9606 (Homo sapiens) [Search protein sequence]

DWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGV
FIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTD
QNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTI
LSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEG
LSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAP
NTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHV
AVTNVVPFETTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITS
YTAQEPDTFQKITYRIWRDTANWLEINPDTGAISTRREDFEHVKNSTYTA
LIIATDNVATGTGTLLLIVNDN

3D structure

PDB

7stz Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography.

Chain

Resolution

2.95 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	BMA	D	A205 T206	A205 T206
BS02	BMA	D	T314 T316	T311 T313
BS03	BMA	D	S126 V127 M128 E129	S126 V127 M128 E129
BS04	BMA	D	T316 A317 T318	T313 A314 T315
BS05	CA	D	E232 E291 V326 E328	E232 E291 V323 E325
BS06	CA	D	E119 E182 D213 T214 D216 D248	E119 E182 D213 T214 D216 D248
BS07	CA	D	E328 E358 D360 Q365 D415	E325 E355 D357 Q360 D406
BS08	CA	D	E11 D67 E69 D103	E11 D67 E69 D103
BS09	CA	D	E11 E69 D100 Q101 D103 D136	E11 E69 D100 Q101 D103 D136
BS10	CA	D	N102 N104 D134 D136 N143 D195	N102 N104 D134 D136 N143 D195
BS11	CA	D	N215 N217 D246 D248 A254 N304	N215 N217 D246 D248 A254 N304
BS12	CA	D	E343 E397	E340 E388
BS13	CA	D	E119 D180 E182 D216	E119 D180 E182 D216
BS14	CA	D	D289 E291 E328	D289 E291 E325
BS15	CA	D	E343 E397 V434 D436	E340 E388 V419 D421

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609	cell-cell adhesion

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7stz, PDBe:7stz, PDBj:7stz
PDBsum	7stz
PubMed	36157596
UniProt	P12830\|CADH1_HUMAN Cadherin-1 (Gene Name=CDH1)

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