Structure of PDB 7sgl Chain D

Receptor sequence
>7sglD (length=406) Species: 9606 (Homo sapiens) [Search protein sequence]
MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRR
LECSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEAS
GEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELL
HSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYH
VVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRN
TQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRK
TNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDK
VVEILKPLCRSSQSTEPKYKPLGKLKRARTVHRDSEEEDDYLFDDPLPIP
LRHKVP
3D structure
PDB7sgl Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
ChainD
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Gene Ontology
Molecular Function
GO:0000014 single-stranded DNA endodeoxyribonuclease activity
GO:0003684 damaged DNA binding
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0008409 5'-3' exonuclease activity
GO:0035312 5'-3' DNA exonuclease activity
Biological Process
GO:0000723 telomere maintenance
GO:0002250 adaptive immune response
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0010212 response to ionizing radiation
GO:0030183 B cell differentiation
GO:0033151 V(D)J recombination
GO:0036297 interstrand cross-link repair
GO:0051276 chromosome organization
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0070419 nonhomologous end joining complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sgl, PDBe:7sgl, PDBj:7sgl
PDBsum7sgl
PubMed34936881
UniProtQ96SD1|DCR1C_HUMAN Protein artemis (Gene Name=DCLRE1C)

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