Structure of PDB 7sbn Chain D

Receptor sequence
>7sbnD (length=406) Species: 9606 (Homo sapiens) [Search protein sequence]
LLPSLEDLLFYTIAEQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLT
LQTTSVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYES
AKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSC
VKPLKYAIAVNDLGTEYVHRYVGKEPSGLRLFLNEDDKPHNPMVNAGAIV
VTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFA
IGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFC
PITGERVLSPEAVRNTLSLMHSCGMWDFSGQFAFHVGLPAKSGVAGGILL
VVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
DPRREG
3D structure
PDB7sbn High-resolution structures of mitochondrial glutaminase C tetramers indicate conformational changes upon phosphate binding.
ChainD
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.2: glutaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLN D Y249 Q285 S286 N335 E381 N388 Y414 G483 V484 Y112 Q148 S149 N195 E241 N248 Y274 G343 V344
Gene Ontology
Molecular Function
GO:0004359 glutaminase activity
Biological Process
GO:0006541 glutamine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7sbn, PDBe:7sbn, PDBj:7sbn
PDBsum7sbn
PubMed34999118
UniProtO94925|GLSK_HUMAN Glutaminase kidney isoform, mitochondrial (Gene Name=GLS)

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