Structure of PDB 7s8c Chain D

Receptor sequence

>7s8cD (length=612) Species: 9606 (Homo sapiens)

ESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRG
AMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVV
NQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSE
EIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHG
DHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTST
LYDLTEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLKWKRYGR
PYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQEA
YMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTILGGPFH
VLIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLG
PFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDY
PMALFSTFELFLTIIDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIA
MMGDTHWRVAHERDELWRAQIVATTVMLERKLPRCLWPRSGICGREYGLG
DRWFLRVEDRQD

3D structure

• PDB: 7s8c Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
• Chain: D
• Resolution: 2.85 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ECL	D	W495 L496	W469 L470
BS02	Y01	D	I557 T558	I531 T532
BS03	Y01	D	S556 I564	S530 I538
BS04	ECL	D	M466 F468 A469 F472 M474 L475	M440 F442 A443 F446 M448 L449
BS05	Y01	D	L332 I335 Y336 Y339 V391 I394 I398 E403 G423 F425 H426 Y467	L306 I309 Y310 Y313 V365 I368 I372 E377 G397 F399 H400 Y441
BS06	Y01	D	F425 S455 F456 V459 L460 C463 R470 T479 I480 I482 Q483 Q596	F399 S429 F430 V433 L434 C437 R444 T453 I454 I456 Q457 Q570
BS07	Y01	D	C494 M497 P527 L530 F531 F534	C468 M471 P501 L504 F505 F508

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005262 calcium channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0006816 calcium ion transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7s8c, PDBe:7s8c, PDBj:7s8c
• PDBsum: 7s8c
• PubMed: 34725357
• UniProt: Q9H1D0|TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6 (Gene Name=TRPV6)