Structure of PDB 7s8b Chain D

Receptor sequence

>7s8bD (length=612) Species: 9606 (Homo sapiens)

ESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRG
AMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVV
NQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSE
EIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHG
DHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTST
LYDLTEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLKWKRYGR
PYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQEA
YMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTILGGPFH
VLIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLG
PFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDY
PMALFSTFELFLTIIDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIA
MMGDTHWRVAHERDELWRAQIVATTVMLERKLPRCLWPRSGICGREYGLG
DRWFLRVEDRQD

3D structure

• PDB: 7s8b Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
• Chain: D
• Resolution: 2.43 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	Y01	D	C494 M497 P527 F531	C468 M471 P501 F505
BS02	R2R	D	T539 D542	T513 D516
BS03	Y01	D	I557 A561 I565	I531 A535 I539
BS04	Y01	D	D550 S556 I557	D524 S530 I531
BS05	Y01	D	Y339 I398 I399 V402 E403 G423 F425 H426 Y467	Y313 I372 I373 V376 E377 G397 F399 H400 Y441
BS06	Y01	D	P424 F425 V459 C463 T479 I480 I482 Q483 Q596	P398 F399 V433 C437 T453 I454 I456 Q457 Q570

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005262 calcium channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0006816 calcium ion transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7s8b, PDBe:7s8b, PDBj:7s8b
• PDBsum: 7s8b
• PubMed: 34725357
• UniProt: Q9H1D0|TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6 (Gene Name=TRPV6)