Structure of PDB 7rgg Chain D

Receptor sequence
>7rggD (length=402) Species: 9606 (Homo sapiens) [Search protein sequence]
SLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQ
TTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYES
AKKQSGGKVADKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKY
AIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTS
LIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGY
YLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPIT
GERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVP
NVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPR
RE
3D structure
PDB7rgg New insights into the molecular mechanisms of glutaminase C inhibitors in cancer cells using serial room temperature crystallography.
ChainD
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.2: glutaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 04A D K320 L321 F322 D327 Y394 K398 K177 L178 F179 D184 Y251 K255
Gene Ontology
Molecular Function
GO:0004359 glutaminase activity
Biological Process
GO:0006541 glutamine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7rgg, PDBe:7rgg, PDBj:7rgg
PDBsum7rgg
PubMed34954143
UniProtO94925|GLSK_HUMAN Glutaminase kidney isoform, mitochondrial (Gene Name=GLS)

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