Structure of PDB 7res Chain D

Receptor sequence
>7resD (length=482) Species: 9606 (Homo sapiens) [Search protein sequence]
GGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTR
KITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKV
KKFEQGFITDPVVLSPSHTVGDVLEAKMRHGFSGIPITETGTLVGIVTSR
DIDFLAEKDVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDEL
VAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGV
DVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGV
DGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQ
TVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLD
AMEKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSM
MYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
3D structure
PDB7res IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
ChainD
Resolution3.05 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0034774 secretory granule lumen
GO:0035578 azurophil granule lumen
GO:1904813 ficolin-1-rich granule lumen

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7res, PDBe:7res, PDBj:7res
PDBsum7res
PubMed35013599
UniProtP20839|IMDH1_HUMAN Inosine-5'-monophosphate dehydrogenase 1 (Gene Name=IMPDH1)

[Back to BioLiP]