Structure of PDB 7re0 Chain D

Receptor sequence
>7re0D (length=185) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
SSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQ
RKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNI
INNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEI
QQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRA
3D structure
PDB7re0 Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex.
ChainD
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna D K61 Q65 K55 Q59
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008242 omega peptidase activity
GO:0016740 transferase activity

View graph for
Molecular Function
External links
PDB RCSB:7re0, PDBe:7re0, PDBj:7re0
PDBsum7re0
PubMed35260847
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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