Structure of PDB 7ras Chain D

Receptor sequence
>7rasD (length=610) Species: 10090 (Mus musculus) [Search protein sequence]
KKKRLKKRIFAAVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTA
SDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYE
GQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGET
PLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQN
DFVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSRE
IKEKPLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEIIVYNTNID
NRHEMLTLEPLHTLLHTKWKKFAKYMFFLSFCFYFFYNITLTLVSYYRHK
MSWLQLLGRMFVLIWATCISVKEGIAIFLLQSILSDAWFHFVFFVQAVLV
ILSVFLYLFAYKEYLACLVLAMALGWANMLAYTRGFQSMGMYSVMIQKVI
LHDVLKFLFVYILFLLGFGVALASLIGSFSDAVLELFKLTIGLGDLNIQQ
NSTYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQR
ARTILEFEKMLPEWLRSRFRMGELCKVADEDFRLCLRINEVKWTEWKTHV
SFLNEDPGPI
3D structure
PDB7ras Structural mechanism of TRPV3 channel inhibition by the plant-derived coumarin osthole.
ChainD
Resolution3.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A0O D S444 C496 I497 E501 M706 S330 C368 I369 E373 M560
BS02 A0O D H426 H430 W433 R693 R696 H312 H316 W319 R547 R550
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0009266 response to temperature stimulus
GO:0042636 negative regulation of hair cycle
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043235 receptor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ras, PDBe:7ras, PDBj:7ras
PDBsum7ras
PubMed34472684
UniProtQ8K424|TRPV3_MOUSE Transient receptor potential cation channel subfamily V member 3 (Gene Name=Trpv3)

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