Structure of PDB 7qy7 Chain D

Receptor sequence
>7qy7D (length=378) Species: 9606 (Homo sapiens) [Search protein sequence]
DLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLV
IGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNA
LVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHF
ELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQK
YLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVRIL
LELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRR
QKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRE
NRYIVLAKDFEKAYKTVIKKDEQEHEFY
3D structure
PDB7qy7 Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5
ChainD
Resolution4.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP D R323 P324 R326 R284 P285 R287
BS02 ATP D G168 P208 G211 K212 T213 M214 I348 A373 N376 G130 P170 G173 K174 T175 M176 I309 A334 N337
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0001824 blastocyst development
GO:0006508 proteolysis
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0016234 inclusion body
GO:0022624 proteasome accessory complex
GO:0031597 cytosolic proteasome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qy7, PDBe:7qy7, PDBj:7qy7
PDBsum7qy7
PubMed37595557
UniProtP43686|PRS6B_HUMAN 26S proteasome regulatory subunit 6B (Gene Name=PSMC4)

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