Structure of PDB 7qwr Chain D

Receptor sequence

>7qwrD (length=292) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]

FVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMI
VRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTG
LLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLAR
TTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQ
NVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPV
YEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERA

3D structure

PDB

7qwr Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	D	F3 V4 K5 A11 K14 R15 Y16 Q17 K19 R23 T28 D29 Y31 R35 L36 K43 Y44 K48 F113 P139 G140 Y145 R152 T153 F160 P174 H175 S176 R179 R268 A274 Q275 D278 R279 Q282	F1 V2 K3 A9 K12 R13 Y14 Q15 K17 R21 T26 D27 Y29 R33 L34 K41 Y42 K46 F111 P137 G138 Y143 R150 T151 F158 P172 H173 S174 R177 R266 A272 Q273 D276 R277 Q280
BS02	rna	D	K10 F13 K14 Y16 V18 F20 R22 R24 T28 Y30 R33 R50 I52 R54 T56 N57 R58 I61 Q63 E70 D72 M73 I74 Y79 N94 R152 T155 G156 N157 K158 H198 N203 V204 Y207 Q222 F223 Y226 Y253 K255 K256 K258 R259 E260 V261 K262 K263 W266 N267 K270 M271 L273 K276 K277 R279 V280 K284	K8 F11 K12 Y14 V16 F18 R20 R22 T26 Y28 R31 R48 I50 R52 T54 N55 R56 I59 Q61 E68 D70 M71 I72 Y77 N92 R150 T153 G154 N155 K156 H196 N201 V202 Y205 Q220 F221 Y224 Y251 K253 K254 K256 R257 E258 V259 K260 K261 W264 N265 K268 M269 L271 K274 K275 R277 V278 K282

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7qwr, PDBe:7qwr, PDBj:7qwr
PDBsum	7qwr
PubMed	35201867
UniProt	P19949\|RL5_RABIT Large ribosomal subunit protein uL18 (Gene Name=RPL5)

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