Structure of PDB 7qq6 Chain D

Receptor sequence
>7qq6D (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRI
KGEVTLLSRLHHENIVRYYNAWIERHERPEAVHYLYIQMEYCEKSTLRDT
IDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRNLKPVNIFLDSDDHVK
IGDFGLATDHLAALYVSPEVQSAYNQKVDLFSLGIIFFEMSYHPMVTASE
RIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELL
KSELLPPPQM
3D structure
PDB7qq6 The structure of human GCN2 reveals a parallel, back-to-back kinase dimer with a plastic DFG activation loop motif.
ChainD
Resolution2.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 38O D L596 A617 M802 E803 Y804 C805 S808 D812 F855 L13 A34 M89 E90 Y91 C92 S95 D99 F142
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7qq6, PDBe:7qq6, PDBj:7qq6
PDBsum7qq6
PubMed31868900
UniProtQ9P2K8|E2AK4_HUMAN eIF-2-alpha kinase GCN2 (Gene Name=EIF2AK4)

[Back to BioLiP]