Structure of PDB 7qne Chain D

Receptor sequence
>7qneD (length=343) Species: 9606 (Homo sapiens) [Search protein sequence]
TVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTI
DVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNM
TMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAY
TRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVV
MTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTT
VLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTK
RGYAWDGKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNR
3D structure
PDB7qne Differential assembly diversifies GABA A receptor structures and signalling.
ChainD
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CL D V53 Q190 V41 Q178
BS02 EIE D H102 G158 S159 Y160 S205 T207 Y210 H90 G146 S147 Y148 S193 T195 Y198
BS03 PIO D R249 T306 F310 K312 R313 S388 S390 K391 I392 L395 R237 T294 F298 K300 R301 S313 S315 K316 I317 L320
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004890 GABA-A receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7qne, PDBe:7qne, PDBj:7qne
PDBsum7qne
PubMed35355020
UniProtP14867|GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1 (Gene Name=GABRA1)

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