Structure of PDB 7qcd Chain D

Receptor sequence
>7qcdD (length=326) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
PVTGDATAKYLLQYILSARGICHENALILALMRLETDASTLNTEWSIQQW
VDKLNDYINAINVKLNLLGYKIIRINHGIGRNAVTLKAKQNFESFEDNTA
IRAHNNDYAVLQSIVLPESNRFFVYVNLASTEETKLATRFNQNEIEFMKW
AIEQFMISGETIVEGPALETSIIVKEVNRILVAATGDSNLAKWRKFSTFT
VGSTNLFQFQELTATDIEDLLLRLCELKWFYRTQEGKFGIDLRCIAELEE
YLTSMYNLNTCQNCHKLAIQGVRCGNESCREENEETGENSLSQIWHVDCF
KHYITHVSKNCDRCGSSLITEGVYVI
3D structure
PDB7qcd Cryo-EM structure of the Smc5/6 holo-complex.
ChainD
Resolution8.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C271 C274 H275 K276 H306 C261 C264 H265 K266 H296
BS02 ZN D C289 C321 R323 C324 C279 C311 R313 C314
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0019789 SUMO transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006281 DNA repair
GO:0006301 postreplication repair
GO:0006310 DNA recombination
GO:0016925 protein sumoylation
GO:0032204 regulation of telomere maintenance
GO:0140588 chromatin looping
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0030915 Smc5-Smc6 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qcd, PDBe:7qcd, PDBj:7qcd
PDBsum7qcd
PubMed35993814
UniProtQ07913|NSE1_YEAST Non-structural maintenance of chromosomes element 1 (Gene Name=NSE1)

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