Structure of PDB 7px0 Chain D

Receptor sequence

>7px0D (length=1236) Species: 7227 (Drosophila melanogaster)

AGRITINGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCV
CTLTGIHPEGELRTWAVNSCLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQ
RLAKMNGTQCGYCSPGIVMNMYGLLKSKGGKVTMEEVENSFGGNICRCTG
YRPILDAMKSFAVDSNIQVQPKGSQLYPDGSRWSWPVSLGDLFAALQGAV
KEKLPYMLVAGNTAHGVYRRSPDIKAFIDVSGLAELKGHKLSADNSSLTL
GGNLSLSETMELCRQLENTKGFEYLSQVWQHLDWIANVPVRNAGTLAGNL
SIKHAHPEFPSDVFIVLEALDAQVIVQEAVDKQQTVSLASYLGSSMEGKI
IRGLVLRAYPKERFAFDSYKIMPRAQNAHAYVNAAFLVEFTADAKVKSAR
ICFGGIHPEFVHATAIENLIRDKNPFENGLVEKAFGQLSTLLQPDAVLPD
ASPVYRRKLACGLFYKFLLKIAAQRKQGLGSRFVTGGSLLKRPVSSGQQS
FETFQEHYPVTKATEKHEGLIQCSGEATYSNDLPTQHNQLWAAFVIAKKV
GAKVTKVDTQPALDLPGVVAYLDAKDIPGPNYVGPKIRDQFFFPKDEELF
ATGEIKFYGQPVGIILANSNSLANRAAELVKLTYEGGAEEILPSLKAVLD
KVNKRLEQPIKSTIDVLQLEEPFDVSSSGQLDMGLQYHYYMEPQTTVVLP
FEGGLQVYAATQWMDLTQDTIANVLNLKSNDVQVKTRRIGGGYGGKATRC
NLAAAAAALAAHKLNRPIRFVQSLESIMTSLGKRWAFHCDYDFFVQKSGK
ISGIVSRFYEDAGYLANESPIGHTVLLSKNCYEFSDNYKLDGYLVCTDSP
SNTPCRAPGSVEGIAMMENIIEHIAFETGVDPADVRFANLLPAHKMGDMM
PRFLESTKYRERKAEAIAHNKENRWHKRGLGLCIMEYQIGYFGQYPATVA
IYHSDGTVVVSHGGIEMGQGMNTKISQVAAHTLGIPMEQVRIEASDTING
ANSMVTGGAVGSETLCFAVRKACETLNERLKPVREEVKPENWQDLIQEAY
NRKINLIASDQCKQGDMDPYSVCGLCLTEVELDVLTGNYIVGRVDILEDT
GESLNPNVDIGQIEGAFMMGLGYWTSEQVIADPKTGECLTNRTWTYKPPG
AKDIPTDLRIELLPKSPNKAGFMRSKATGEPAICLSIAVAFALQQALQSA
RDDAGVPKSWVTLTAPMTPEHLVLHSGTEPSQFKLN

3D structure

• PDB: 7px0 Drosophila melanogaster's Aldehyde Oxidase 1: The First Invertebrate AOX structure
• Chain: D
• Resolution: 2.2 Å

Enzymatic activity

• Enzyme Commision number: 1.2.3.8: pyridoxal oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FES	D	Q111 C112 G113 C115 C148 C150 M728	Q109 C110 G111 C113 C146 C148 M691
BS02	FES	D	F40 C42 Q43 G45 C47 G48 C50 C72	F39 C41 Q42 G44 C46 G47 C49 C70
BS03	FAD	D	G45 L239 A241 G242 N243 T244 A245 V248 N284 I316 A317 V321 G325 T326 A328 G329 N330 S332 I333 F340 S342 D343 I381 I382 K401 W1181	G44 L208 A210 G211 N212 T213 A214 V217 N253 I285 A286 V290 G294 T295 A297 G298 N299 S301 I302 F309 S311 D312 I350 I351 K370 W1144

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004031 aldehyde oxidase activity
• GO:0004732 pyridoxal oxidase activity
• GO:0005506 iron ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0050660 flavin adenine dinucleotide binding
• GO:0051536 iron-sulfur cluster binding
• GO:0051537 2 iron, 2 sulfur cluster binding
• GO:0071949 FAD binding

Biological Process

• GO:0042817 pyridoxal metabolic process

Cellular Component

• GO:0005777 peroxisome
• GO:0005829 cytosol

External links

• PDB: RCSB:7px0, PDBe:7px0, PDBj:7px0
• PDBsum: 7px0
• UniProt: Q9VF53