Structure of PDB 7pga Chain D

Receptor sequence
>7pgaD (length=341) Species: 1924,1950,1114943 [Search protein sequence]
IDALRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALAARTDTRPE
ALLRLIRHLVAIGLLEEDAPGEFVPTEVGELLADDHPAAQRAWHDLTQAV
ARADISFTRLPDAIRTGRPTYESIYGKPFYEDLAGRPDLRASFDSLMTTR
EDTAFAAPAAAYDWTNVRHVLDVGGGKGGFAAAIARRAPHVSATVLEMAG
TVDTARSYLKDEGLSDRVDVVEGDFFEPLPRKADAIILSFVLLNWPDHDA
VRILTRCAEALEPGGRILIHERADVEGDGADRFFSTLLDLRMLVFLGGAL
RTREKWDGLAASAGLVVEEVRGPLVSPNVPLDSCLLVLAPA
3D structure
PDB7pga Evolution-inspired engineering of anthracycline methyltransferases.
ChainD
Resolution2.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.292: carminomycin 4-O-methyltransferase.
4.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH D Y143 R153 G187 G188 G189 E210 M211 G236 D237 F238 S252 Y130 R140 G174 G175 G176 E197 M198 G223 D224 F225 S239
BS02 VAK D W106 F156 M160 F253 N257 F297 L300 L301 R304 M305 F308 L344 W93 F143 M147 F240 N244 F284 L287 L288 R291 M292 F295 L331
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7pga, PDBe:7pga, PDBj:7pga
PDBsum7pga
PubMed36874276
UniProtI2N5E8;
Q06528|DNRK_STRPE Carminomycin 4-O-methyltransferase DnrK (Gene Name=dnrK);
Q54527|RDMB_STREF Aclacinomycin 10-hydroxylase RdmB (Gene Name=rdmB)

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