Structure of PDB 7oih Chain D

Receptor sequence

>7oihD (length=571) Species: 9606 (Homo sapiens)

CPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPG
VKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFT
PEPAAVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSN
ITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNG
RALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREH
NRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMR
KYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNP
RVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLF
EQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRN
LKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLR
DGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSY
PRDFVNCSTLPALNLASWREA

3D structure

• PDB: 7oih Native glycosylation and binding of the antidepressant paroxetine in a low-resolution crystal structure of human myeloperoxidase.
• Chain: D
• Resolution: 2.603 Å

Enzymatic activity

• Enzyme Commision number: 1.11.2.2: myeloperoxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MAN	D	F605 K671	F432 K498
BS02	SCN	D	R197 L199 N492 V493 L596 W602	R31 L33 N319 V320 L423 W429
BS03	CA	D	D262 T334 F336 D338 S340	D96 T161 F163 D165 S167
BS04	HEM	D	M253 G256 Q257 D260 D264 F265 T266 E408 M409 R499 G501 H502 I505 L583 R590	M87 G90 Q91 D94 D98 F99 T100 E235 M236 R326 G328 H329 I332 L410 R417
BS05	SCN	D	H261 R405 E408	H95 R232 E235
BS06	8PR	D	E268 P386 T404 V576	E102 P213 T231 V403

Gene Ontology

Molecular Function

• GO:0004601 peroxidase activity
• GO:0020037 heme binding

Biological Process

• GO:0006979 response to oxidative stress

External links

• PDB: RCSB:7oih, PDBe:7oih, PDBj:7oih
• PDBsum: 7oih
• PubMed: 36048150
• UniProt: P05164|PERM_HUMAN Myeloperoxidase (Gene Name=MPO)