Structure of PDB 7o45 Chain D

Receptor sequence
>7o45D (length=84) Species: 9606 (Homo sapiens) [Search protein sequence]
MASDVANNKSSLEDGCLSCGSFHPLFEGGLCQCTVCCEGRELLLCCVECL
EVLVGTSCYMCLPQRCHGVLRRRKDWNVRLQAFF
3D structure
PDB7o45 Structure of the DNMT3B ADD domain suggests the absence of a DNMT3A-like autoinhibitory mechanism.
ChainD
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C435 S437 C438 C455 C16 S18 C19 C31
BS02 ZN D C478 C481 C500 C503 C33 C36 C46 C49
BS03 ZN D C490 C524 C527 C45 C58 C61
External links
PDB RCSB:7o45, PDBe:7o45, PDBj:7o45
PDBsum7o45
PubMed35760008
UniProtQ9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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