Structure of PDB 7nz1 Chain D

Receptor sequence

>7nz1D (length=575) Species: 37762 (Escherichia coli B)

PAWQTRDHLDDPVIGELRNRFGPDAFTVQATRTGVPVVWIKREQLLEVGD
FLKKLPKPYVMLFDLHGMDERLRTHREGLPAADFSVFYHLISIDRNRDIM
LKVALAENDLHVPTFTKLFPNANWYERETWDLFGITFDGHPNLRRIMMPQ
TWKGHPLRKDYPARATEFSPFELTKAKQDLEMEALTFKPEEWGMKRGDFM
FLNLGPHGAFRIVLQLIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRI
EYLGGCVNEMPYVLAVEKLAGITVPDRVNVIRVMLSELFRINSHLLYIST
FIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRG
WDRLLREFLDWMPKRLASYEKAALQNTILKGRSQGVAAYGAKEALEWGTT
GAGLRATGIDFDVRKARPYSGYENFDFEIPVGGGVSDCYTRVMLKVEELR
QSLRILEQCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWG
PVMPANESFQMIEATKGINSYYLTSDGSTMSYRTRVRTPSFAHLQQIPAA
IRGSLVSDLIVYLGSIDFVMSDVDR

3D structure

• PDB: 7nz1 Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation.
• Chain: D
• Resolution: 2.1 Å

Enzymatic activity

• Enzyme Commision number: 7.1.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	D	R250 R270	R229 R249

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0003954 NADH dehydrogenase activity
• GO:0005515 protein binding
• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0016651 oxidoreductase activity, acting on NAD(P)H
• GO:0048038 quinone binding
• GO:0050136 NADH:ubiquinone reductase (non-electrogenic) activity
• GO:0051287 NAD binding

Biological Process

• GO:0022904 respiratory electron transport chain
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005737 cytoplasm
• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0030964 NADH dehydrogenase complex
• GO:0045271 respiratory chain complex I

External links

• PDB: RCSB:7nz1, PDBe:7nz1, PDBj:7nz1
• PDBsum: 7nz1
• PubMed: 34308841
• UniProt: P33599|NUOCD_ECOLI NADH-quinone oxidoreductase subunit C/D (Gene Name=nuoC)