Structure of PDB 7nyd Chain D

Receptor sequence
>7nydD (length=487) Species: 9606 (Homo sapiens) [Search protein sequence]
VTLMPIDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSDKEV
EDCVTNRPCRSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRR
IYKKCQHEMDQYWGIGSLASGINLFTNSFEGPVLDHRYYAGGCSPHYILN
TRFRKPYNVESYTPQTQGKYEFILKEYESYSDFERNVTEKMASKDRGKHY
IRRTKRFSHTKSVFLHARSDLEVAHYKLKPRSLMLHYEFLQRVKRLPLEY
SYGEYRDLFRDFGTHYITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHAR
GILNEIKDRNKRDTMVEDLVVLVRGGASEHITTLAYQELPTADLMQEWGD
AVQYNPAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCH
CAPCQGNGVPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNW
SSCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS
3D structure
PDB7nyd Structural basis of soluble membrane attack complex packaging for clearance.
ChainD
Resolution3.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMA D E440 K444 N499 W500 E390 K394 N449 W450
BS02 BMA D W19 R29 W16 R26
BS03 CA D L84 N87 D89 D91 D97 E98 L81 N84 D86 D88 D94 E95
Gene Ontology
Molecular Function
GO:0044877 protein-containing complex binding
Biological Process
GO:0006955 immune response
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0031640 killing of cells of another organism
GO:0050778 positive regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular exosome
GO:1903561 extracellular vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nyd, PDBe:7nyd, PDBj:7nyd
PDBsum7nyd
PubMed34667172
UniProtP07358|CO8B_HUMAN Complement component C8 beta chain (Gene Name=C8B)

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