Structure of PDB 7nnq Chain D

Receptor sequence

>7nnqD (length=344) Species: 83332 (Mycobacterium tuberculosis H37Rv)

ATKVAVAGASGYAGGEILRLLLGHPAYADGRLRIGALTAATSAGSTLGEH
HPHLTPLAHRVVEPTEAAVLGGHDAVFLALPHGHSAVLAQQLSPETLIID
CGADFRLTDAAVWERFYGSSHAGSWPYGLPELPGARDQLRGTRRIAVPGC
YPTAALLALFPALAADLIEPAVTVVAVSGTSGAGRAATTDLLGAEVIGSA
RAYNIAGVHRHTPEIAQGLRAVTDRDVSVSFTPVLIPASRGILATCTART
RSPLSQLRAAYEKAYHAEPFIYLMPEGQLPRTGAVIGSNAAHIAVAVDED
AQTFVAIAAIDNLVKGTAGAAVQSMNLALGWPETDGLSVVGVAP

3D structure

• PDB: 7nnq A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis
• Chain: D
• Resolution: 1.73 Å

Enzymatic activity

• Enzyme Commision number: 1.2.1.38: N-acetyl-gamma-glutamyl-phosphate reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	D	G16 S18 G19 Y20 A21 A47 A48 T49 S50 T73 A87 L88 P89 H92 C109 C158 G190 G192 R193 L321 G324 T325	G8 S10 G11 Y12 A13 A39 A40 T41 S42 T65 A79 L80 P81 H84 C101 C150 G182 G184 R185 L313 G316 T317

Gene Ontology

Molecular Function

• GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity
• GO:0005515 protein binding
• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
• GO:0051287 NAD binding
• GO:0070401 NADP+ binding

Biological Process

• GO:0006526 L-arginine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7nnq, PDBe:7nnq, PDBj:7nnq
• PDBsum: 7nnq
• UniProt: P9WPZ9|ARGC_MYCTU N-acetyl-gamma-glutamyl-phosphate reductase (Gene Name=argC)