Structure of PDB 7nbq Chain D

Receptor sequence
>7nbqD (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
GFTSKDTYLSHFNPRDYLEKYYKFGSAESQILKHLLKNLFKIFCLDGVKG
DLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKAAPAAFD
WSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPP
ADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMI
GEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLV
ARKLS
3D structure
PDB7nbq Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders.
ChainD
Resolution2.479 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.1: nicotinamide N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH D Y11 Y20 Y25 S64 T67 Y69 D85 Y86 N90 D142 T163 L164 A169 Y8 Y17 Y22 S58 T61 Y63 D79 Y80 N84 D136 T157 L158 A163 BindingDB: IC50=35300nM
BS02 U72 D Y20 L164 A198 S201 Y204 S213 Y242 A247 Y17 L158 A192 S195 Y198 S207 Y236 A241
Gene Ontology
Molecular Function
GO:0008112 nicotinamide N-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0030760 pyridine N-methyltransferase activity
Biological Process
GO:0006769 nicotinamide metabolic process
GO:0009410 response to xenobiotic stimulus
GO:0031100 animal organ regeneration
GO:0032259 methylation
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0045722 positive regulation of gluconeogenesis
GO:0090312 positive regulation of protein deacetylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:7nbq, PDBe:7nbq, PDBj:7nbq
PDBsum7nbq
PubMed33668468
UniProtP40261|NNMT_HUMAN Nicotinamide N-methyltransferase (Gene Name=NNMT)

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