Structure of PDB 7n15 Chain D

Receptor sequence
>7n15D (length=520) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
YAVRIRKYLANYTQDPSTDNFYYWTCVVTVAYIYNLLFVIARQVFNDLIG
PSSQSLCRFYNGTLNSTTQVECTYNMLTNMKEMPTYSQYPDLGWSKYWHF
RMLWVFFDLLMDCVYLIDTFLNYRMGYMDQGLVVREAEKVTKAYWQSKQY
RIDGISLIPLDYILGWPIPYINWRGLPILRLNRLIRYKRVRNCLERTETR
SSMPNAFRVVVVVWYIVIIIHWNACLYFWISEWIGLGTDAWVYGHLNKQS
LPDDITDTLLRRYVYSFYWSTLILTTIGEVPSPVRNIEYAFVTLDLMCGV
LIFATIVGNVGSMISNMSAAWTEFQNKMDGIKQYMELRKVSKQLEIRVIK
WFDYLWTNKQSLSDQQVLKVLPDKLQAEIAMQVHFETLRKVRIFQDCEAG
LLAELVLKLQLQVFSPGDFICKKGDIGREMYIVKRGRLQVVDDDGKKVFV
TLQEGSVFGELSILNIAGSKNGNRRTANVRSVGYTDLFVLSKTDLWNALR
EYPDARKLLLAKGREILKKD
3D structure
PDB7n15 Structural and functional characterization of an achromatopsia-associated mutation in a phototransduction channel.
ChainD
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PCG D F558 G559 L561 S562 R575 T576 A577 D620 F458 G459 L461 S462 R475 T476 A477 D520
BS02 CPL D Y134 D147 L148 C172 Y174 Y197 F200 W204 F207 Y34 D47 L48 C72 Y74 Y97 F100 W104 F107
BS03 CPL D I133 W314 I33 W214
BS04 CPL D Y315 I318 W322 Y215 I218 W222
BS05 CPL D V317 H321 L360 Y363 V217 H221 L260 Y263
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity
GO:0005222 intracellularly cAMP-activated cation channel activity
GO:0005223 intracellularly cGMP-activated cation channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0030553 cGMP binding
GO:0042802 identical protein binding
GO:0044877 protein-containing complex binding
Biological Process
GO:0003031 detection of carbon dioxide
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0006935 chemotaxis
GO:0007199 G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007399 nervous system development
GO:0007602 phototransduction
GO:0007635 chemosensory behavior
GO:0009454 aerotaxis
GO:0010628 positive regulation of gene expression
GO:0010754 negative regulation of cGMP-mediated signaling
GO:0019722 calcium-mediated signaling
GO:0030516 regulation of axon extension
GO:0034220 monoatomic ion transmembrane transport
GO:0040010 positive regulation of growth rate
GO:0040040 thermosensory behavior
GO:0042048 olfactory behavior
GO:0043052 thermotaxis
GO:0045664 regulation of neuron differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048609 multicellular organismal reproductive process
GO:0048812 neuron projection morphogenesis
GO:0050907 detection of chemical stimulus involved in sensory perception
GO:0055085 transmembrane transport
GO:0055093 response to hyperoxia
GO:0070482 response to oxygen levels
GO:0071805 potassium ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0016020 membrane
GO:0017071 intracellular cyclic nucleotide activated cation channel complex
GO:0030425 dendrite
GO:0034703 cation channel complex
GO:0042995 cell projection
GO:0097543 ciliary inversin compartment
GO:0097730 non-motile cilium

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7n15, PDBe:7n15, PDBj:7n15
PDBsum7n15
PubMed35233102
UniProtQ03611|CNG_CAEEL Cyclic nucleotide-gated channel (Gene Name=tax-4)

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