Structure of PDB 7moa Chain D

Receptor sequence
>7moaD (length=638) Species: 9606 (Homo sapiens) [Search protein sequence]
KRRNTIHEFKKSAKTTLIKIDPIKTKKVNTADQCANRCTRNKGLPFTCKA
FVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSY
KGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGG
PWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWD
HQTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIK
TCTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFKCKDLR
ENYCRNPDGSESPWCFTTDPNIRVGYCSQIPNCQDCYRGNGKNYMGNLSQ
TRSGLTCSMWDKNMEDLHRHIFWEKLNENYCRNPDDDAHGPWCYTGNPLI
PWDYCPISRCVVNGIPTRTNIGWMVSLRYRNKHICGGSLIKESWVLTARQ
CFPSRDLKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKL
ARPAVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHL
YIMGNEKCSQHHRGKVTLNESEICAGAEKIGSGPCEGDYGGPLVCEQHKM
RMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKIILT
3D structure
PDB7moa Structural basis of the activation of c-MET receptor.
ChainD
Resolution4.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q534 D578 E670 G671 D672 Y673
Catalytic site (residue number reindexed from 1) Q450 D494 E586 G587 D588 Y589
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SGN D K60 K62 L80 W98 K24 K26 L44 W62
BS02 IDS D K62 R73 K26 R37
BS03 SGN D Q69 R73 R76 K78 G79 Q33 R37 R40 K42 G43
BS04 IDS D R36 R76 N77 K78 R3 R40 N41 K42
BS05 SGN D K34 R35 R36 K1 R2 R3
BS06 IDS D K34 R36 K1 R3
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7moa, PDBe:7moa, PDBj:7moa
PDBsum7moa
PubMed34210960
UniProtP14210|HGF_HUMAN Hepatocyte growth factor (Gene Name=HGF)

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