Structure of PDB 7miv Chain D

Receptor sequence
>7mivD (length=542) Species: 10090 (Mus musculus) [Search protein sequence]
MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYINIDAGTF
SPYEHGEVFVLNDGGEVDLDLGNYERFLDINLYKDNNITTGKIYQHVINK
ERRGDYLGKTVQVVPHITDAIQEWVMNQAKVSVDGNKEDPQICVIELGGT
IGDIEGMAFVEAFRQFQFKAKKENFYNIHVSLVPQPSATGEQKTKPTQNS
VRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSST
YRVPLLLEEQGVVKYFQERLGLPLLFKWKAMADRYERLQKICSIALVGKY
TKLRDCYASVFKALEHSALAINHKLNLMYIDSIDLEPVTKAEDPVKFHEA
WQKLCLADGILVPGGFGIRGTLGKLQAISWARTKKIPFLGICLGMQLAVI
EFARNCLNLKDANSTEFEPNTPVPLVIDMPETMRLGLRRTVFTTENSILK
KLYGDVPYIEERHRHRYEVNPNLINQFENKDLCFVGEDVDGKRMEIVELT
SHPYFIGVQFHPEFSSRPMKPSPPYLGLLLAATGNLNAHLQQ
3D structure
PDB7miv Structural basis for isoform-specific inhibition of human CTPS1.
ChainD
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.2: CTP synthase (glutamine hydrolyzing).
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003883 CTP synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0016879 ligase activity, forming carbon-nitrogen bonds
GO:0042802 identical protein binding
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006541 glutamine metabolic process
GO:0044210 'de novo' CTP biosynthetic process
Cellular Component
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7miv, PDBe:7miv, PDBj:7miv
PDBsum7miv
PubMed34583994
UniProtP70303|PYRG2_MOUSE CTP synthase 2 (Gene Name=Ctps2)

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