Structure of PDB 7m33 Chain D

Receptor sequence

>7m33D (length=664) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168)

KIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMIDDHILGIE
KTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVD
QAVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVL
LIALYGGLLVFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYF
DNLPAGKVVARITNDTEAIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVK
LAFVALAIVPIIWLWSVIYRRYASYYNQKIRSINSDINAKMNESIQGMTI
IQAFRHQKETMREFEELNESHFYFQNRMLNLNSLMSHNLVNVIRNLAFVA
LIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQFSKLELARV
SAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHISF
TAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQE
LRSHMGIVLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKK
LPKGINEPVIEKGSTLSSGERQLISFARALAFDPAILILDQATAHIDTET
EAVIQKALDVVKQGRTTFVIAHRLSTIRNADQILVLDKGEIVERGNHEEL
MALEGQYYQMYELQ

3D structure

• PDB: 7m33 Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter.
• Chain: D
• Resolution: 3.55 Å

Enzymatic activity

• Enzyme Commision number: 7.6.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	D	S467 K469 S470 S471 I472	S466 K468 S469 S470 I471

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0034040 ATPase-coupled lipid transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0006869 lipid transport
• GO:0046677 response to antibiotic
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:7m33, PDBe:7m33, PDBj:7m33
• PDBsum: 7m33
• PubMed: 34931066
• UniProt: O07549|YHEH_BACSU Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH (Gene Name=yheH)