Structure of PDB 7lr0 Chain D

Receptor sequence
>7lr0D (length=646) Species: 43179 (Ictidomys tridecemlineatus) [Search protein sequence]
LKLYDRRSIFDAVAQNNCQELESLLPFLQKSRKRLTDSEFKDPETGKTCL
LKAMLNLHNGQNDTISLLLDIARQTDSLKEFVNASYTDSYYKGQTALHIA
IERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACT
NQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTADNTKFVTSM
YNEILILGAKLHPTLKLEELINKKGLTPLALAASSGKIGVLAYILQREIQ
EPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPN
RHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIVFTTAAYYRPVD
GLPPYKLKNTVGDYFRVTGEILSVSGGVYFFLRGIQYFLQRRPSMKTLFV
DSYSEMLFFVQSLFMLGSVVLYFSHRKEYVASMVFSLAMGWTNMLYYTRG
FQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGDSYNSL
YSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIA
LMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGY
TPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFS
3D structure
PDB7lr0 Extracellular cap domain is an essential component of the TRPV1 gating mechanism.
ChainD
Resolution3.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4DY D F593 L671 F483 L539
BS02 4DY D S514 L517 F545 T552 L555 Y556 S404 L407 F435 T442 L445 Y446
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0051219 phosphoprotein binding
GO:0097603 temperature-gated ion channel activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001659 temperature homeostasis
GO:0001660 fever generation
GO:0002024 diet induced thermogenesis
GO:0002790 peptide secretion
GO:0006629 lipid metabolic process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0009268 response to pH
GO:0009408 response to heat
GO:0014832 urinary bladder smooth muscle contraction
GO:0019233 sensory perception of pain
GO:0034220 monoatomic ion transmembrane transport
GO:0034605 cellular response to heat
GO:0048265 response to pain
GO:0048266 behavioral response to pain
GO:0050909 sensory perception of taste
GO:0050954 sensory perception of mechanical stimulus
GO:0050955 thermoception
GO:0050960 detection of temperature stimulus involved in thermoception
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050968 detection of chemical stimulus involved in sensory perception of pain
GO:0055085 transmembrane transport
GO:0060083 smooth muscle contraction involved in micturition
GO:0070588 calcium ion transmembrane transport
GO:0071468 cellular response to acidic pH
GO:0098703 calcium ion import across plasma membrane
GO:1901594 response to capsazepine
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032591 dendritic spine membrane
GO:0043005 neuron projection
GO:0045211 postsynaptic membrane
GO:0098982 GABA-ergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lr0, PDBe:7lr0, PDBj:7lr0
PDBsum7lr0
PubMed33846324
UniProtI3LZN5

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