Structure of PDB 7lqy Chain D

Receptor sequence
>7lqyD (length=659) Species: 43179 (Ictidomys tridecemlineatus) [Search protein sequence]
LKLYDRRSIFDAVAQNNCQELESLLPFLQKSRKRLTDSEFKDPETGKTCL
LKAMLNLHNGQNDTISLLLDIARQTDSLKEFVNASYTDSYYKGQTALHIA
IERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACT
NQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTADNTKFVTSM
YNEILILGAKLHPTLKLEELINKKGLTPLALAASSGKIGVLAYILQREIQ
EPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPN
RHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIVFTTAAYYRPVD
GLPPYKLKNTVGDYFRVTGEILSVSGGVYFFLRGIQYFLQRRPSMKTLFV
DSYSEMLFFVQSLFMLGSVVLYFSHRKEYVASMVFSLAMGWTNMLYYTRG
FQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGKNYWRA
PGCRPPDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVI
LTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRK
AFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEG
VKRTLSFSL
3D structure
PDB7lqy Extracellular cap domain is an essential component of the TRPV1 gating mechanism.
ChainD
Resolution3.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YBG D R411 S512 Y513 S514 L517 T552 L555 R559 E572 I575 Q702 R301 S402 Y403 S404 L407 T442 L445 R449 E462 I465 Q582
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0051219 phosphoprotein binding
GO:0097603 temperature-gated ion channel activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001659 temperature homeostasis
GO:0001660 fever generation
GO:0002024 diet induced thermogenesis
GO:0002790 peptide secretion
GO:0006629 lipid metabolic process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0009268 response to pH
GO:0009408 response to heat
GO:0014832 urinary bladder smooth muscle contraction
GO:0019233 sensory perception of pain
GO:0034220 monoatomic ion transmembrane transport
GO:0034605 cellular response to heat
GO:0048265 response to pain
GO:0048266 behavioral response to pain
GO:0050909 sensory perception of taste
GO:0050954 sensory perception of mechanical stimulus
GO:0050955 thermoception
GO:0050960 detection of temperature stimulus involved in thermoception
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050968 detection of chemical stimulus involved in sensory perception of pain
GO:0055085 transmembrane transport
GO:0060083 smooth muscle contraction involved in micturition
GO:0070588 calcium ion transmembrane transport
GO:0071468 cellular response to acidic pH
GO:0098703 calcium ion import across plasma membrane
GO:1901594 response to capsazepine
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032591 dendritic spine membrane
GO:0043005 neuron projection
GO:0045211 postsynaptic membrane
GO:0098982 GABA-ergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lqy, PDBe:7lqy, PDBj:7lqy
PDBsum7lqy
PubMed33846324
UniProtI3LZN5

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