Structure of PDB 7lhz Chain D

Receptor sequence
>7lhzD (length=677) Species: 507522 (Klebsiella pneumoniae 342) [Search protein sequence]
PGKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNT
WEVSSDEVLASQEVHDISVAIGIDPDSDDLSQLRYGKICILADADSDGLH
IATLLCALFVRHFRTLVKEGHVYVALPPLYRIYALTEEEKTGVQRFKGLG
EMNPMQLRETTLDPNTRRLVQLVISDEDEQQTTAIMDMLLAKKRSEDRRN
WLQEKGDERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYA
MSELGLNASAKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYP
LVDGQGNWGAPDDPKSFAAMRYTESRLSKYAELLLSELGQGTVDWVPNFD
GTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAKAAITLIEQ
PKTTLDELLDIVQGPDFPTEAEIITSRAEIRKIYQNGRGSVRMRAVWSKE
DGAVVITALPHQVSGAKVLEQIAAQMRNKKLPMVESDHENPTRLVIVPRS
NRVDMEQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVF
RRDTVRRRLNHRLEKVLKRLHILEGLLVAFLNIDEVIEIIRTEDEPKPAL
MSRFGISETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQAILAS
ERKMNNLLKKELQADADAFGDDRRSPL
3D structure
PDB7lhz Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.
ChainD
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lhz, PDBe:7lhz, PDBj:7lhz
PDBsum7lhz
PubMed33929852
UniProtB5XU53;
B5XU60

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