Structure of PDB 7lfu Chain D

Receptor sequence
>7lfuD (length=306) Species: 694009 (Severe acute respiratory syndrome-related coronavirus) [Search protein sequence]
TIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGK
TFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTS
IKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILA
YSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVE
AVMYMGTLSYDNLKTGVSIPGRDATQYLVQQESSFVMMSAPPAEYKLQQG
TFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYK
ETSYTT
3D structure
PDB7lfu A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease.
ChainD
Resolution2.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D N110 C112 L163 G164 D165 P249 Y265 Y269 G272 H273 Y274 N106 C108 L159 G160 D161 P242 Y258 Y262 G265 H266 Y267
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7lfu, PDBe:7lfu, PDBj:7lfu
PDBsum7lfu
PubMed34547223
UniProtP0C6X7|R1AB_SARS Replicase polyprotein 1ab (Gene Name=rep)

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