Structure of PDB 7les Chain D

Receptor sequence
>7lesD (length=447) Species: 1257118 (Acanthamoeba castellanii str. Neff) [Search protein sequence]
GKLPPVVSSLIPFVGSGLSFAGGPLQYTTDAYKKYGDIFTMKVFGQRLTF
LVGPDAHVPFFSQGDAELSQDEPYQFSVPIFGPNVVYGADLAHRNQQLKF
IAASLSTKALQSYVPLIVKEAEDFFAKWDKSGTVDIRDALAELIILTASR
CLMGKEIRENLFTEVAKLYQTLDEGLLPISVFFPYLPIPAHKRRDEARLA
MVRMFKKIIDERRANPEVKHNDCLQVFMDARYRGEEQALNDEEITGLMIA
LLFAGQHTSSVTGSWTGLLLFEANNKKKFLPGVLEEQEEIRKEFGDELTM
EALNKMDKLHRCVKEALRMYPPLLFVMRKVIKPFSYKDYYVPEGDTVFVS
PALSMRVEEVFPNADQYNPERFVEEDKQAQKYRFVGFGAGRHGCMGENFA
YLQIKTIWSVLLRNFDIELVGELPKPDYTAMVVGPAHPCLLRYTRKH
3D structure
PDB7les Homodimerization Counteracts the Detrimental Effect of Nitrogenous Heme Ligands on the Enzymatic Activity of Acanthamoeba castellanii CYP51.
ChainD
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM D Y114 A294 G295 T298 P362 V366 R368 G426 F427 H432 C434 G436 Y74 A254 G255 T258 P322 V326 R328 G386 F387 H392 C394 G396
BS02 IMD D A294 T298 A254 T258
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008168 methyltransferase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0032259 methylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7les, PDBe:7les, PDBj:7les
PDBsum7les
PubMed35730528
UniProtL8GJB3

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