Structure of PDB 7l2x Chain D

Receptor sequence
>7l2xD (length=536) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SYTDSYYKGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGR
PGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALV
EVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAAS
SGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEK
NSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYC
LYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRG
IQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMV
FSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFS
TAVVTLIEDGKYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLA
YVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKC
MRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTT
3D structure
PDB7l2x Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
ChainD
Resolution3.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6EU D F591 L669 F399 L454 BindingDB: Ki=0.13nM,IC50=180nM
BS02 6EU D S512 L515 M547 T550 Y554 R557 I569 S320 L323 M355 T358 Y362 R365 I377 BindingDB: Ki=0.13nM,IC50=180nM
BS03 6IY D M581 Y631 F638 M389 Y416 F423
BS04 XPJ D G643 M644 G428 M429
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7l2x, PDBe:7l2x, PDBj:7l2x
PDBsum7l2x
PubMed34496225
UniProtO35433|TRPV1_RAT Transient receptor potential cation channel subfamily V member 1 (Gene Name=Trpv1)

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