Structure of PDB 7l24 Chain D

Receptor sequence
>7l24D (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
IFNRDPRDHYDLLQRLVFKARDKVSGDLVALKMVKMDVSTLQKEILILKT
CRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVC
REVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLAR
RLAFIGTPYWMAPEVAAVALKGCYNELCDIWSLGITAIELAELQPPLFDV
HPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKM
LSHQLVSQPGLNRGLILDLLDKLK
3D structure
PDB7l24 Identification of Potent Reverse Indazole Inhibitors for HPK1.
ChainD
Resolution2.68 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D137 K139 A141 N142 D155 A164 T175
Catalytic site (residue number reindexed from 1) D119 K121 A123 N124 D137 A146 T157
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XHV D L23 V31 A44 M91 C94 A96 G97 L144 D155 L16 V17 A30 M73 C76 A78 G79 L126 D137
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7l24, PDBe:7l24, PDBj:7l24
PDBsum7l24
PubMed33738073
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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