Structure of PDB 7kwe Chain D

Receptor sequence
>7kweD (length=371) Species: 9606 (Homo sapiens) [Search protein sequence]
KPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRL
FEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLT
TQPIPGLSTVIGGSGGSYVFSKTYNVTDDKYGCLSGNIPALELMALYVAA
AMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEY
NFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWT
NENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLG
LPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVERRKIY
CQITQHLLQNHKMWKKVIEEE
3D structure
PDB7kwe Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
ChainD
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X5M D Y751 G953 P954 H961 I968 Q1001 F1004 Y83 G270 P271 H278 I285 Q318 F321
BS02 MN D H756 H836 D837 D950 H88 H153 D154 D267
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:7kwe, PDBe:7kwe, PDBj:7kwe
PDBsum7kwe
PubMed34272366
UniProtQ14432|PDE3A_HUMAN cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Gene Name=PDE3A)

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