Structure of PDB 7krj Chain D

Receptor sequence
>7krjD (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
ATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVI
AAVKWAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLC
FAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLL
SSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLL
DSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKL
LFHQK
3D structure
PDB7krj Structure of Hsp90-p23-GR reveals the Hsp90 client-remodelling mechanism.
ChainD
Resolution2.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DEX D M560 L563 N564 G567 Q570 Y735 T739 M38 L41 N42 G45 Q48 Y213 T217 BindingDB: EC50=2.5nM,Ki=1.2nM,IC50=5nM,Kd=19nM
External links
PDB RCSB:7krj, PDBe:7krj, PDBj:7krj
PDBsum7krj
PubMed34937936
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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