Structure of PDB 7kkq Chain D

Receptor sequence
>7kkqD (length=206) Species: 9606 (Homo sapiens) [Search protein sequence]
GTILLDLAPEDKEYQSVEEEMQSTIREHRDAGGIFNRYNVIRIQKVVNKK
LRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGM
FGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLG
KSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLIT
YQIMKP
3D structure
PDB7kkq Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
ChainD
Resolution1.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 78P D H1184 G1185 Y1213 F1214 A1215 K1220 S1221 Y1224 I1228 E1291 H77 G78 Y106 F107 A108 K113 S114 Y117 I121 E184 BindingDB: IC50=10715nM
BS02 ZN D C1234 H1237 C1242 C1245 C127 H130 C135 C138
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7kkq, PDBe:7kkq, PDBj:7kkq
PDBsum7kkq
PubMed33361107
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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