Structure of PDB 7kho Chain D

Receptor sequence

>7khoD (length=405) Species: 1042876 (Pseudomonas putida S16) [Search protein sequence]

FDYDVVVVGGGFAGATAARECGLQGYRTLLLEARSRLGGRTFTSRFAGQE
IEFGGAWVHWLQPHVWAEMQRYGLGVVEDPLTNLDKTLIMYNDGSVESIS
PDEFGKNIRIAFEKLCHDAWEVFPRPHEPMFTERARELDKSSVLDRIKTL
GLSRLQQAQINSYMALYAGETTDKFGLPGVLKLFACGGWNYDAFMDTETH
YRIQGGTIGLINAMLTDSGAEVRMSVPVTAVEQVNGGVKIKTDDDEIITA
GVVVMTVPLNTYKHIGFTPALSKGKQRFIKEGQLSKGAKLYFAFADEQQP
LNWVQTHDYSSITIARKETIDVNDRDEVQKMFPGVAAYDWTADPFSLGAW
AAYGVGQLSRLKDLQAAEGRILFAGAETSNGWHAVIDGAVESGLRAGREV
KQLLS

3D structure

PDB

7kho Fast Kinetics Reveals Rate-Limiting Oxidation and the Role of the Aromatic Cage in the Mechanism of the Nicotine-Degrading Enzyme NicA2.

Chain

Resolution

2.69 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.4.2.2: nicotine dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NCT	D	Y218 W364 T381 W427	Y167 W303 T313 W350
BS02	FAD	D	G60 G62 A64 E83 A84 R85 G90 R91 G105 G106 A107 W108 P278 V279 V308 P309 W417 F422 G452 A453 A461 V462 I463 A466	G9 G11 A13 E32 A33 R34 G39 R40 G54 G55 A56 W57 P227 V228 V257 P258 W340 F345 G375 A376 A384 V385 I386 A389

Gene Ontology

	Molecular Function
GO:0016491	oxidoreductase activity

View graph for
Molecular Function

External links

PDB	RCSB:7kho, PDBe:7kho, PDBj:7kho
PDBsum	7kho
PubMed	33464876
UniProt	F8G0P2\|NICA2_PSEP6 Nicotine dehydrogenase (Gene Name=nicA2)

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