Structure of PDB 7kfn Chain D

Receptor sequence
>7kfnD (length=355) Species: 9606 (Homo sapiens) [Search protein sequence]
HLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAK
VISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNN
KDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPARGQL
RTKIESGEGTIPVRRLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSI
ILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKA
PNFSVNWTVGDSAIEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPS
HLLRSKITKPNVYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQD
QFSLT
3D structure
PDB7kfn Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position.
ChainD
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IHP D I397 R401 K519 R522 G530 S531 K629 Y658 K662 Y668 K672 K690 I80 R84 K174 R177 G185 S186 K284 Y313 K317 Y323 K327 K345
BS02 ZN D H394 C451 C516 H77 C134 C171
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:7kfn, PDBe:7kfn, PDBj:7kfn
PDBsum7kfn
PubMed33939417
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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