Structure of PDB 7kd7 Chain D

Receptor sequence

>7kd7D (length=202) Species: 9606 (Homo sapiens) [Search protein sequence]

EERAAMDAVCAKVDAANRLGDPLEAFPVFKKYDRNGLNVSIECKRVSGLE
PATVDWAFDLTKTNMQTMYEQSEWGWKDREKREEMTDDRAWYLIAWENSS
VPVAFSHFRFDVECGDEVLYCYEVQLESKVRRKGLGKFLIQILQLMANST
QMKKVMLTVFKHNHGAYQFFREALQFEIDDSSPSMSGCCGEDCSYEILSR
RT

3D structure

PDB

7kd7 Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.

Chain

Resolution

1.44 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

2.3.1.257: N-terminal L-serine N(alpha)-acetyltransferase NatD.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	D	Y85 W90 D127 E129 Y136 Y138 E139 T174 P199 Y211 I213	Y69 W74 D111 E113 Y120 Y122 E123 T158 P183 Y195 I197
BS02	CMC	D	M81 E139 V140 Q141 L142 R147 R148 G150 G152 K153 T174 N179 G181 A182 F185 A189	M65 E123 V124 Q125 L126 R131 R132 G134 G136 K137 T158 N163 G165 A166 F169 A173

Gene Ontology

	Molecular Function
GO:0010485	histone H4 acetyltransferase activity
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups
GO:0043998	histone H2A acetyltransferase activity

View graph for
Molecular Function

External links

PDB	RCSB:7kd7, PDBe:7kd7, PDBj:7kd7
PDBsum	7kd7
PubMed	34110812
UniProt	Q86UY6\|NAA40_HUMAN N-alpha-acetyltransferase 40 (Gene Name=NAA40)

[Back to BioLiP]