Structure of PDB 7k5k Chain D

Receptor sequence
>7k5kD (length=545) Species: 5855 (Plasmodium vivax) [Search protein sequence]
TTVPQVVSLDPTTIPIDYHTPIDDLSIEVKDISAEACPADEGLIVFLLNS
APKHSSSGGSGGNGGSAGSSGNGEGGAQIKINSSVKDNTINEFLKEGNME
NFTGKLGTSKSFYIANDQKKYVSLAYVGCGPANEETELEIRKVAYALVTL
LHDSKHKKVSIIFEIKIEEALFRFFLEHLFYEYVTDERFKSADKSTETDF
IKNLSLHIANADAYKGQIDKARVYFYGTYYAAQLIAAPSNYCNPVSLSNA
AVELAQKVNLECKILDVKELEELKMGAYLSVGKGSMYPNKFIHLTYKGAQ
TGASQNEKKKIALIGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLG
CAYCIGTIKPDNVEVHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNT
DAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNDQ
LINKILSSSKTSNEPVWWLPIINEYRSSLNSKYADLNNISSSVKASSVVA
SLFLKEFIENTPWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLND
3D structure
PDB7k5k Active site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases.
ChainD
Resolution2.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.13.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO3 D A476 G478 R479 L503 A402 G404 R405 L429
BS02 MN D K390 D395 D415 E477 K316 D321 D341 E403
BS03 MN D D395 D475 E477 D321 D401 E403
Gene Ontology
Molecular Function
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7k5k, PDBe:7k5k, PDBj:7k5k
PDBsum7k5k
PubMed33303633
UniProtA5K3U9|AMPL_PLAVS Leucine aminopeptidase (Gene Name=LAP)

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