Structure of PDB 7jxp Chain D

Receptor sequence
>7jxpD (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]
NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE
ATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLL
DYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ
HVKITDFGLAKLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSK
PYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRE
LIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM
3D structure
PDB7jxp Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
ChainD
Resolution2.16 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP D G719 G721 A722 V726 A743 K745 M790 M793 C797 D837 R841 N842 L844 G20 G22 A23 V27 A44 K46 M91 M94 C98 D138 R142 N143 L145
BS02 MG D N842 D855 N143 D156
BS03 JBJ D V726 A743 I744 K745 L747 I759 M766 R776 L777 L788 M790 D855 F856 L858 V27 A44 I45 K46 L48 I60 M67 R77 L78 L89 M91 D156 F157 L159 BindingDB: IC50=>1000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7jxp, PDBe:7jxp, PDBj:7jxp
PDBsum7jxp
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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