Structure of PDB 7jxm Chain D

Receptor sequence
>7jxmD (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE
ATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLL
DYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ
HVKITDFGLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYD
GIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELII
EFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM
3D structure
PDB7jxm Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
ChainD
Resolution2.192 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP D S720 G721 A722 V726 A743 K745 M790 M793 C797 D837 R841 N842 L844 D855 S21 G22 A23 V27 A44 K46 M91 M94 C98 D138 R142 N143 L145 D156
BS02 MG D N842 D855 N143 D156
BS03 9LL D V726 A743 I744 K745 I759 C775 R776 L777 L788 M790 D855 F856 L858 V27 A44 I45 K46 I60 C76 R77 L78 L89 M91 D156 F157 L159 BindingDB: IC50=3.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7jxm, PDBe:7jxm, PDBj:7jxm
PDBsum7jxm
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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