Structure of PDB 7jpp Chain D

Receptor sequence
>7jppD (length=406) Species: 9606 (Homo sapiens) [Search protein sequence]
LSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLII
GPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITR
QLNLENVVGDKVFGSFAENLSFLLEACPVIFILDEFDLFAHHKNQTLLYN
LFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFGFPQ
YVKIFKEQLSLPAEFPDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKN
LRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCSMDSKANIVHGLSVLE
ICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKA
FEHLQQLELIKPMERTSGNSQREYQLMKLLLDNTQIMNALQKYPNCPTDV
RQWATS
3D structure
PDB7jpp The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures.
ChainD
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP D Q31 H34 F38 G70 S71 G72 K73 T74 M75 L276 R277 Q15 H18 F22 G54 S55 G56 K57 T58 M59 L251 R252
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0040038 polar body extrusion after meiotic divisions
GO:0051258 protein polymerization
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7jpp, PDBe:7jpp, PDBj:7jpp
PDBsum7jpp
PubMed32808929
UniProtO43929|ORC4_HUMAN Origin recognition complex subunit 4 (Gene Name=ORC4)

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