Structure of PDB 7jn7 Chain D

Receptor sequence
>7jn7D (length=799) Species: 9606 (Homo sapiens) [Search protein sequence]
DDPAARFQVQKHSWDGLRSIIHGSRKPHDFQFVQKTDESGPHSHRLYYLG
LLYSEIPKKVRKEALLLLSWKQMLITSYDFHSESGLFLFQASNSLFHCRD
GGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANI
ETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASW
EGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPK
IALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYA
WAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYE
EVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQ
GYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVY
FQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYS
SVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFH
TRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRL
NTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAE
KYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDT
GYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFF
HTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL
3D structure
PDB7jn7 Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment.
ChainD
Resolution3.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y644 S730 Y731 D808 H840
Catalytic site (residue number reindexed from 1) Y580 S666 Y667 D744 H776
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GK2 D E248 E249 Y644 S730 Y731 Y762 Y766 N810 V811 E184 E185 Y580 S666 Y667 Y698 Y702 N746 V747
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis
GO:0043069 negative regulation of programmed cell death
GO:0070269 pyroptotic inflammatory response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005874 microtubule
GO:0031252 cell leading edge

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7jn7, PDBe:7jn7, PDBj:7jn7
PDBsum7jn7
PubMed34019797
UniProtQ86TI2|DPP9_HUMAN Dipeptidyl peptidase 9 (Gene Name=DPP9)

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