Structure of PDB 7h8c Chain D

Receptor sequence
>7h8cD (length=159) Species: 37124 (Chikungunya virus) [Search protein sequence]
PSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATP
VGTAKTVMCGTYPVIHAVGPNFSNYTESEGDRELAAAYREVAKEVTRLGV
NSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKK
ISEAIQMRT
3D structure
PDB7h8c Group deposition for crystallographic fragment screening of Chikungunya virus nsP3 macrodomain
ChainD
Resolution1.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XJV D A22 G32 V33 L108 A21 G31 V32 L107
BS02 XJV D A22 D31 V113 Y114 A21 D30 V112 Y113
BS03 XJV D D10 I11 A36 R144 D9 I10 A35 R143
External links
PDB RCSB:7h8c, PDBe:7h8c, PDBj:7h8c
PDBsum7h8c
PubMed
UniProtQ8JUX6|POLN_CHIKS Polyprotein P1234

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