Structure of PDB 7fgy Chain D

Receptor sequence
>7fgyD (length=562) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
QKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRGKR
FNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQR
VRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITR
VAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDN
EATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAAGLQAPSSAAAIAPVL
AWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDR
TGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANH
LSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMH
TDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQ
FYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFI
HFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFE
VVGYVPHGRIQM
3D structure
PDB7fgy Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase.
ChainD
Resolution2.67 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.3: dihydrofolate reductase.
2.1.1.45: thymidylate synthase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004146 dihydrofolate reductase activity
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016491 oxidoreductase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation
GO:0046654 tetrahydrofolate biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7fgy, PDBe:7fgy, PDBj:7fgy
PDBsum7fgy
PubMed35715223
UniProtQ07422|DRTS_TOXGO Bifunctional dihydrofolate reductase-thymidylate synthase

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